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Because of the risk of hypokalaemia the concomitant administration of hydrochlorothiazide and medicinal products that induce torsades de pointese.gsome antiarrhythmicssome anti-psychotics and other drugs known to induce torsades de pointesshould be used with caution.

The potassium losing effect of thiazide diuretics is usually attenuated by the potassium conserving effect of lisinoprilThe use of potassium supplementspotassium-sparing agents or potassium-containing salt substitutes and other medicinal products that may increase serum potassium levelsparticularly in patients with impaired renal function or diabetes mellitusmay lead to a significant increase in serum potassiumIf concomitant use of lisinopril/hydrochlorothiazide and any of these agents is requiredthey should be used with caution and with frequent monitoring of serum potassiumsee section 4.4

Because no information is available regarding the use of lisinopril/hydrochlorothiazide during breast-feedinglisinopril/hydrochlorothiazide is not recommended and alternative treatments with better established safety profiles during breast-feeding are preferableespecially while nursing a newborn or preterm infant.

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