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Before prescribing diflucan fluconazole for aids patients with cryptococcal meningitis, please see clinical studies section.

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Secreted in human milk at concentrations similar to maternal plasma concentrationsuse cautionAAP Committee statescompatible with nursing

See ContraindicationsAvoid concomitant voriconazoleif neededmonitor closely espwhen given within 24hrs after fluconazoleCaution with amiodaroneespwith high-dose fluconazoleother drugs metabolized by CYP2C9 and CYP3A4 with a narrow therapeutic windowPotentiates warfarinoral hypoglycemicsoral midazolamtriazolamtofacitinibalfentanilamitriptylinenortriptylinesaquinavirtacrolimussirolimuscarbamazepinemethadoneNSAIDszidovudineadjust dose as necessaryMay increase levels of phenytointheophyllinehalofantrinerifabutinvinca alkaloidscyclosporinefentanylcalcium channel blockerslosartanmonitorConcomitant celecoxibreduce celecoxib dose by halfIncreased risk of myopathy/rhabdomyolysis with concomitant HMG-CoA reductase inhibitorsclosely monitorMay be potentiated by diureticsMay be antagonized by oral cimetidinerifampinConcomitant prednisonemonitor for adrenal cortex insufficiency when fluconazole stoppedCNS effects with Vitamin AOral contraceptivessee full labelingAvoid other hepatotoxic drugs.

Many drugs can interact with fluconazoleand some drugs should not be used togetherThis includes prescription and over-the-counter medicinesvitaminsand herbal productsNot all possible interactions are listed in this medication guideTell your doctor about all your current medicines and any medicine you start or stop using.

Hepatotoxicity reported with useuse with caution in patients with hepatic impairment.

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